Modulators of diabetic neuropathy and inflammation from Saponaria officinalis: Isolation of active phytochemicals and potential mechanisms of action

  • 25 Mar 2023
  • Published Resarch - Pharmacy


Karim Raafat and Mazen al Haj

Published in

Journal of Traditional and Complementary Medicine, in press, corrected proof, 5 January 2023. (Citable using the year of online publication and the DOI)



Natural metabolites are rich in neuroactive and anti-inflammatory phytochemicals. Soapwort or Saponaria officinalis (Sap) has been utilized for its immunomodulatory and ant-rheumatic properties. Thus, the aim is to exploit Sap phytochemically and to investigate Sap isolated active phytochemicals effect to modulate diabetic neuropathy and inflammation, and their possible mechanisms of action.

Keywords: Saponaria officinalis – Quillaic acid – Diabetic Neuropathy – Inflammation.

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